Chronic neuropathy with IgM antiganglioside antibodies:: Lack of long term response to rituximab

被引：69

作者：

Rojas-García, R

Gallardo, E

de Andrés, I

de Luna, N

Juarez, C

Sánchez, P

Illa, I

机构：

[1] Hosp Sta Creu & St Pau, Dept Neurol, Neuromuscular Unit, Barcelona, Spain

[2] Hosp Sta Creu & St Pau, Lab Expt Neurol, Barcelona, Spain

[3] Hosp Sta Creu & St Pau, Dept Immunol, Barcelona, Spain

[4] Univ Autonoma Barcelona, Inst Rec HSCSP, E-08193 Barcelona, Spain

[5] Clin Puerta de Hierro, Dept Neurol, Madrid, Spain

来源：

NEUROLOGY | 2003年 / 61卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000098996.02934.86

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two patients with chronic motor neuropathy, high antiganglioside antibody (AGA) titers, and a declining response to IV immunoglobulins were treated with rituximab at a standard dose. The drug was well tolerated and effectively eliminated peripheral B cells (CD20+), but AGA titers continued significantly high. No clinical improvement was detected during the 1-year follow-up.

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页码：1814 / 1816

页数：3

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