Aneugenic and clastogenic effects of doxorubicin in human lymphocytes

被引：53

作者：

Dhawan, A

Kayani, MA

Parry, JM

Parry, E

Anderson, D ^{[2
]}

机构：

[1] Ind Toxicol Res Ctr, Lucknow 226001, Uttar Pradesh, India

[2] Univ Bradford, Dept Biomed Sci, Bradford BD7 1DP, W Yorkshire, England

[3] Univ Coll Swansea, Ctr Mol Genet & Toxicol, Swansea SA2 8PP, W Glam, Wales

来源：

MUTAGENESIS | 2003年 / 18卷 / 06期

关键词：

D O I：

10.1093/mutage/geg024

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Doxorubicin, a benzanthroquinone anticancer agent, was examined for its effect on micronucleus induction in cultured human lymphocytes. A statistically significant dose-dependent increase in micronucleus frequency (P < 0.001) in binucleated cells was seen and an increase in the kinetochore-positive (P < 0.001) and kinetochore-negative micronuclei (P < 0.001) was observed. An increase was also observed in the number of necrotic cells, but the frequency of apoptotic cells remained almost constant. This confirms that doxorubicin is both clastogenic and aneugenic.

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页码：487 / 490

页数：4

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