Evaluation of the radioprotective effects of propolis and flavonoids in gamma-irradiated mice: The alkaline comet assay study

被引：52

作者：

Benkovic, Vesna ^{[1
]}

Orsolic, Nada ^{[1
]}

Knezevic, Anica Horvat ^{[1
]}

Ramic, Snjezana ^{[2
]}

Dikic, Domagoj ^{[1
]}

Basic, Ivan ^{[1
]}

Kopjar, Nevenka ^{[3
]}

机构：

[1] Univ Zagreb, Fac Sci, Dept Anim Physiol, HR-10000 Zagreb, Croatia

[2] Univ Zagreb, Univ Hosp Tumors, HR-10000 Zagreb, Croatia

[3] Inst Med Res & Occupat Hlth, HR-10000 Zagreb, Croatia

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2008年 / 31卷 / 01期

关键词：

radioprotection; propolis; flavonoid; mouse; alkaline comet assay;

D O I：

10.1248/bpb.31.167

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The radioprotective effects of water-soluble derivate of propolis (WSDP) collected in Croatia, and single flavonoids, caffeic acid, chrysin and naringin in the whole-body irradiated CBA mice were investigated. Irradiation was performed using a gamma-ray source (Co-60), and absorbed doses were 4 and 9 Gy. The efficiency of test components was evaluated when given intraperitoneally (i.p.) at dose of 100 mg kg(-1) for 3 consecutive days before and/or after irradiation. Moreover, possible genotoxic effects of all test components were assessed on non-irradiated animals. The higher efficiency of test components was observed when given preventively. The results suggest that propolis and related flavonoid's given to mice before irradiation protected mice from lethal effects of whole-body irradiation and diminish primary DNA damage in their white blood cells as detected by the alkaline comet assay.

引用

页码：167 / 172

页数：6

共 31 条

[1] Chemical diversity of propolis and the problem of standardization [J].