Subjective cognitive impairment: Functional MRI during a divided attention task

被引：75

作者：

Rodda, J. ^{[1
,2
]}

Dannhauser, T. ^{[1
,2
]}

Cutinha, D. J. ^{[1
,2
]}

Shergill, S. S. ^{[3
,4
]}

Walker, Z. ^{[1
,2
]}

机构：

[1] UCL, Dept Mental Hlth Sci, London W1T 4JF, England

[2] N Essex Partnership NHS Fdn Trust, Chelmsford, Essex, England

[3] Inst Psychiat, London SE5 8AF, England

[4] UCL, Inst Neurol, Wellcome Dept Imaging Sci, London W1T 4JF, England

来源：

EUROPEAN PSYCHIATRY | 2011年 / 26卷 / 07期

基金：

英国惠康基金;

关键词：

Mild cognitive impairment; fMRI; Subjective memory complaints; Attention; Aging and cognition; Subjective cognitive impairment; ALZHEIMERS-DISEASE; MEMORY COMPLAINTS; BRAIN ACTIVATION; WORKING-MEMORY; EPSILON-4; ALLELE; VISUAL-ATTENTION; FMRI; PATTERNS; CORTEX; RISK;

D O I：

10.1016/j.eurpsy.2010.07.003

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Individuals with subjective cognitive impairment (SCI) have persistent memory complaints but normal neurocognitive performance. For some, this may represent a pre-mild cognitive impairment (MCI) stage of Alzheimer's disease (AD). Given that attentional deficits and associated brain activation changes are present early in the course of AD, we aimed to determine whether SCI is associated with brain activation changes during attentional processing. Methods: Eleven SCI subjects and 10 controls completed a divided attention task during functional magnetic resonance imaging. Results: SCI and control groups did not differ in sociodemographic, neurocognitive or behavioural measures. When group activation during the divided attention task was compared, the SCI group demonstrated increased activation in left medial temporal lobe, bilateral thalamus, posterior cingulate and caudate. Conclusion:This pattern of increased activation is similar to the pattern of decreased activation reported during divided attention in AD and may indicate compensatory changes. These findings suggest the presence of early functional changes in SCI; longitudinal studies will help to further elucidate the relationship between SCI and AD. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：457 / 462

页数：6

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