n-3 Dietary supplementation and lipid metabolism: Differences between vegetable- and fish-derived oils

被引：24

作者：

Campioli, Enrico ^{[1
]}

Rustichelli, Cecilia ^{[2
]}

Avallone, Rossella ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Biomed Sci, I-41125 Modena, Italy

[2] Univ Modena & Reggio Emilia, Dept Pharmaceut Sci, I-41125 Modena, Italy

来源：

JOURNAL OF FUNCTIONAL FOODS | 2012年 / 4卷 / 01期

关键词：

n-3; PUFAs; Flaxseed oil; Fish oil; PPAR; Rat; POLYUNSATURATED FATTY-ACIDS; ALPHA-LINOLENIC ACID; RANDOMIZED CONTROLLED-TRIAL; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; HEPATIC STEATOSIS; RHEUMATOID-ARTHRITIS; ALZHEIMERS-DISEASE; MAJOR DEPRESSION; SERUM;

D O I：

10.1016/j.jff.2011.10.006

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The effect of flaxseed oil rich in linolenic acid (ALA), and a mixed oil (flaxseed oil and fish oil) rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the lipid clearance and peroxisome proliferator activated receptors (PPARs) in liver and adipose tissue of rats fed for 30 days with the two oils was evaluated. The results showed that after treatment with the mixed oil the hematic triacylglycerol content was significantly decreased compared to control animals. Regarding the tissue distribution of the major omega-3 fatty acids, both oils were able to increase ALA, EPA, docosapentaenoic acid (DPA) in liver and adipose tissue; and DHA solely in the adipose tissue. Finally the treatment with either flaxseed or mixed oil increased hepatic PPAR-gamma expression but only the mixed oil enhanced the hepatic expression of PPAR-alpha. No effect on adipose tissue PPAR-gamma expression was observed with both oils' treatment. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：207 / 212

页数：6

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