Chromosome abnormalities in colorectal adenomas: Two cytogenetic subgroups characterized by deletion of 1p and numerical aberrations

被引:24
作者
Bomme, L
Bardi, G
Pandis, N
Fenger, C
Kronborg, O
Heim, S
机构
[1] ODENSE UNIV HOSP,DEPT PATHOL,DK-5000 ODENSE,DENMARK
[2] ODENSE UNIV HOSP,DEPT GASTROINTESTINAL SURG,DK-5000 ODENSE,DENMARK
[3] ST SAVAS HOSP,DEPT GENET,ATHENS,GREECE
[4] UNIV LUND HOSP,DEPT CLIN GENET,S-22185 LUND,SWEDEN
[5] NORWEGIAN RADIUM HOSP,INST CANC RES,DEPT GENET,OSLO,NORWAY
关键词
cytogenetics; colorectal; adenoma; chromosome deletion; chromosome aberrations;
D O I
10.1016/S0046-8177(96)90314-7
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Cytogenetic analysis of short-term cultures from 34 benign colorectal polyps, all histologically verified as adenomas, revealed clonal chromosome aberrations in 21 of them. Eight polyps had structural rearrangements, whereas only numerical changes were found in 13. A combination of structure and numerical chromosomal aberrations was found in three polyps. The most common numerical change was gain of chromosome 7, found either as the sole anomaly (five polyps), together with other numerical changes (six polyps), or together with structural rearrangements (two polyps). Other recurrent numerical changes were +20, +13, and monosomy 18, found in six, five, and two adenomas, respectively. Rearrangement of chromosome 1 was the most common structural change. Abnormalities involving 1p were seen in six adenomas, leading to visible loss of material in three. One adenoma had one clone with a large and another with a small 1p deletion. In three adenomas, del(1)(p36) was the only cytogenetic aberration, supporting the authors' previous conclusion that loss of one or more gene loci in band 1p36 is a common early change in colorectal tumorigenesis. Chromosome 8 was involved in structural changes in two adenomas; in one this led to loss of 8p and in the other to gain of 8q. The cytogenetic findings did not correlate in a statistically significant manner with clinicopathologic parameters, such as grade of dysplasia, macroscopic or microscopic adenoma structure, tumor size and location, or the patients' sex and age. Copyright (C) 1996 by W.B. Saunders Company
引用
收藏
页码:1192 / 1197
页数:6
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