The role of SHIP in cytokine-induced signaling

被引:79
作者
Kalesnikoff, J
Sly, LM
Hughes, MR
Büchse, T
Rauh, MJ
Cao, LP
Lam, V
Mui, A
Huber, M
Krystal, G
机构
[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
[2] Vancouver Hosp & Hlth Sci Ctr, Jack Bell Res Ctr, Vancouver, BC V5Z 1M9, Canada
[3] Univ Freiburg, Dept Mol Immunol, D-79108 Freiburg, Germany
[4] Max Planck Inst Immunobiol, D-79108 Freiburg, Germany
来源
REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 149 | 2004年 / 149卷
关键词
D O I
10.1007/s10254-003-0016-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The phosphatidylinositol (PI)-3 kinase (PI3K) pathway plays a central role in regulating many biological processes via the generation of the key second messenger PI-3,4,5-trisphosphate (PI-3,4,5-P-3). This membrane-associated phospholipid, which is rapidly, albeit transiently, synthesized from PI-4,5-P-2 by PI3K in response to a diverse array of extracellular stimuli, attracts pleckstrin homology (PH) domain-containing proteins to membranes to mediate its many effects, To ensure that the activation of this pathway is appropriately suppressed/terminated, the ubiquitously expressed tumor suppressor PTEN hydrolyzes PI-3,4,5-P-3 back to PI-4,5-P-2 while the 145-kDa hemopoietic-restricted SH2-containing inositol 5'-phosphatase, SHIP (also known as SHIP1), the 104-kDa stem cell-restricted SHIP (sSHIP) and the more widely expressed 150-kDa SHIP2 hydrolyze PI-3,4,5-P-3 to PI-3,4-P-2. In this review we will concentrate on the properties of the three SHIPs, with special emphasis being placed on the role that SHIP plays in cytokine-induced signaling.
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页码:87 / 103
页数:17
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