A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases

被引：68

作者：

Hunt, MC ^{[1
]}

Yamada, J

Maltais, LJ

Wright, MW

Podesta, EJ

Alexson, SEH

机构：

[1] Karolinska Univ, Huddinge Hosp, Dept Lab Med, Div Clin Chem C174,Karolinska Inst, Stockholm, Sweden

[2] Tokyo Univ Pharm & Life Sci, Dept Clin Biochem, Tokyo, Japan

[3] Jackson Lab, Mouse Genome Informat, Mouse Genom Nomenclature Committee, Bar Harbor, ME 04609 USA

[4] UCL, London, England

[5] Univ Buenos Aires, Sch Med, Dept Biochem, Buenos Aires, DF, Argentina

来源：

JOURNAL OF LIPID RESEARCH | 2005年 / 46卷 / 09期

关键词：

fatty acid metabolism; coenzyme A; peroxisomes;

D O I：

10.1194/jlr.E500003-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branchedchain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee and the Mouse Genomic Nomenclature Committee, a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged.

引用

页码：2029 / 2032

页数：4

共 25 条

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