MicroRNA therapeutics

被引：336

作者：

Broderick, J. A. ^{[2
]}

Zamore, P. D. ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01609 USA

[2] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Neurosci, Worcester, MA 01605 USA

来源：

GENE THERAPY | 2011年 / 18卷 / 12期

关键词：

miRNA; antagomir; anti-miR; Argonaute; RNA silencing; miRNA inhibition; PROGRESSIVE HEARING-LOSS; IN-VIVO; ONCOLYTIC ADENOVIRUS; RNA INTERFERENCE; MAMMALIAN-CELLS; GENE-EXPRESSION; MESSENGER-RNAS; CANCER; TARGETS; REPLICATION;

D O I：

10.1038/gt.2011.50

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) provide new therapeutic targets for many diseases, while their myriad roles in development and cellular processes make them fascinating to study. We still do not fully understand the molecular mechanisms by which miRNAs regulate gene expression nor do we know the complete repertoire of mRNAs each miRNA regulates. However, recent progress in the development of effective strategies to block miRNAs suggests that anti-miRNA drugs may soon be used in the clinic. Gene Therapy (2011) 18, 1104-1110; doi:10.1038/gt.2011.50; published online 28 April 2011

引用

页码：1104 / 1110

页数：7

共 67 条

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