New oxygenated Cephalotaxus alkaloids from Cephalotaxus harringtonia var drupacea

被引：16

作者：

Takano, I ^{[1
]}

Yasuda, I ^{[1
]}

Nishijima, M ^{[1
]}

Hitotsuyanagi, Y ^{[1
]}

Takeya, K ^{[1
]}

Itokawa, H ^{[1
]}

机构：

[1] TOKYO UNIV PHARM & LIFE SCI,HACHIOJI,TOKYO 19203,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 12期

关键词：

D O I：

10.1021/np9605044

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three oxygenated cephalotaxine ester-type alkaloids, 11 alpha-hydroxyhomodeoxyharringtonine (1), 11 beta-hydroxyhomodeoxyharringtonine (2) and 11 beta-hydroxydeoxyharringtonine (3) were isolated hom Cephalatoxus harringtonia var. drupacea. Their structures were established by spectroscopic methods including 2D NMR and CD spectra,and their antileukemic activity was evaluated using P-388 leukemia cells.

引用

页码：1192 / 1195

页数：4

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