Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

被引:177
作者
Batten, Marcel [1 ]
Kljavin, Noelyn M. [1 ]
Li, Ji [1 ]
Walter, Michael J. [2 ]
de Sauvage, Frederic J. [1 ]
Ghilardi, Nico [1 ]
机构
[1] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
[2] Washington Univ, Sch Med Pulm & Crit Care Med, St Louis, MO 63110 USA
关键词
D O I
10.4049/jimmunol.180.5.2752
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The cytokine IL-27 is important for restricting inflammation in response to a wide variety of immune challenges. In this study, we demonstrate that IL-27 induces expression of the anti-inflammatory cytokine IL-10 by CD4(+) and CD8(+) T cells. IL-27 relied upon the Th1 transcription factor STAT1 to induce IL-10(+)IFN-gamma(+)FoxP3(-) Th1 cells, which were recently shown to be key negative regulators during certain infections. IL27ra(-/-) mice generated fewer IL-10(+) T cells during both Listeria monocytogenes infection and experimental autoimmune encephalomyelitis. The data presented here indicate a novel mechanism for the induction of IL-10 expression by T cells and provide a mechanistic basis for the suppressive effects of IL-27.
引用
收藏
页码:2752 / 2756
页数:5
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