Polymorphisms in ADAR1 gene affect response to interferon alpha based therapy for chronic hepatitis B in Han Chinese

被引：15

作者：

Wu, Xiaopan ^{[1
]}

Xin, Zhenhui ^{[1
]}

Zhu, Xilin ^{[1
]}

Pan, Liping ^{[1
]}

Li, Zhuo ^{[2
]}

Li, Hui ^{[3
]}

Liu, Ying ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Natl Lab Med Mol Biol, Inst Basic Med Sci,Sch Basic Med, Beijing 100005, Peoples R China

[2] Capital Univ Med Sci, Affiliated Youan Hosp, Dept Infect Dis, Beijing 100005, Peoples R China

[3] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Dept Epidemiol,Inst Basic Med Sci, Beijing 100005, Peoples R China

来源：

ANTIVIRAL RESEARCH | 2012年 / 94卷 / 03期

关键词：

IFN pathway gene; Chronic hepatitis B; Interferon alpha therapy; Single nucleotide polymorphism; Sustained virological response; ADENOSINE-DEAMINASE GENE; VIRUS-INFECTION; ASSOCIATION; MANAGEMENT; RIBAVIRIN; PATHWAY; IL28B;

D O I：

10.1016/j.antiviral.2012.03.004

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Host genetic polymorphisms in interferon pathway genes are reported to be associated with response to interferon therapy. Five hundred and forty-eight a interferon treatment-naive chronic hepatitis B patients were enrolled in the retrospective nested case-control study. All patients received a interferon based treatment and were examined for therapy efficacy. We genotyped 115 polymorphisms from 16 interferon pathway genes using the MassArray system. We identified rs4845384 in ADAR1 gene is strongly associated with the outcome of interferon therapy allele dose-depended (P=0.0005), with decreased odds ratios of 0.69 and 0.27 for GA and AA genotypes, respectively (95% confidence interval, 0.47-0.99 for GA; 0.11-0.64 for AA). Our study suggested that rs4845384 in ADAR1 associates with treatment-induced clearance of chronic hepatitis B. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：272 / 275

页数：4

共 24 条

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