Multicomponent reactions involving zwitterionic intermediates for the construction of heterocyclic systems: one pot synthesis of aminofurans and iminolactones

被引：114

作者：

Nair, V ^{[1
]}

Vinod, AU

Abhilash, N

Menon, RS

Santhi, V

Varma, RL

Viji, S

Mathew, S

Srinivas, R

机构：

[1] CSIR, Reg Res Lab, Organ Chem Div, Trivandrum 695019, Kerala, India

[2] CISR, Indian Inst Chem Technol, Natl Ctr Mass Spect, Hyderabad, Andhra Pradesh, India

来源：

TETRAHEDRON | 2003年 / 59卷 / 51期

关键词：

isocyanides; multicomponent reactions; dimethyl acetylenedicarboxylate; aldehydes;

D O I：

10.1016/j.tet.2003.10.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 1: 1 zwitterionic intermediate generated in situ from dimethyl acetylenedicarboxylate (DMAD) and cyclohexyl isocyanide with aldehydes and quinones is described. The reaction of stoichiometric amounts of DMAD, isocyanide and aldehydes afforded 2-aminofurans in good yields, while the reaction with quinones gave iminolactones. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：10279 / 10286

页数：8

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