Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics

被引：29

作者：

Li, TL ^{[1
]}

Choroba, OW ^{[1
]}

Charles, EH ^{[1
]}

Sandercock, AM ^{[1
]}

Williams, DH ^{[1
]}

Spencer, JB ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge Ctr Mol Recognit, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 18期

关键词：

D O I：

10.1039/b103548g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

ORF22 from the chloroeremomycin gene cluster has been cloned, expressed and characterised as a hydroxymandelate oxidase (HmO) that is involved in the formation of both (S)-4-hydroxyphenylglycine and (S)-3,5-dihydroxyphenylglycine.

引用

页码：1752 / 1753

页数：2

共 13 条

[1] IDENTIFICATION AND CHARACTERIZATION OF GLYCOLATE OXIDASE AND RELATED ENZYMES FROM THE ENDOCYANOTIC ALGA CYANOPHORA-PARADOXA AND FROM PEA LEAVES [J].

BETSCHE, T ;

SCHALLER, D ;

MELKONIAN, M .

PLANT PHYSIOLOGY, 1992, 98 (03) :887-893

[2] Biosynthesis of the vancomycin group of antibiotics:: Involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine [J].

Choroba, OW ;

Williams, DH ;

Spencer, JB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (22) :5389-5390

[3] INVITRO EFFECTS OF VANCOMYCIN, RIFAMPICIN, AND FUSIDIC ACID, ALONE AND IN COMBINATION, AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS [J].

FOLDES, M ;

MUNRO, R ;

SORRELL, TC ;

SHANKER, S ;

TOOHEY, M .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 11 (01) :21-26

[4]

Gazaryan IG, 1997, BIOCHEM J, V328, P643

[5] ON THE BIOSYNTHESIS OF THE ANTIBIOTIC VANCOMYCIN [J].

HAMMOND, SJ ;

WILLIAMSON, MP ;

WILLIAMS, DH ;

BOECK, LD ;

MARCONI, GG .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (06) :344-346

[6] THE BIOSYNTHESIS OF RISTOCETIN [J].

HAMMOND, SJ ;

WILLIAMS, DH ;

NIELSEN, RV .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1983, (03) :116-117

[7] Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics [J].

Hubbard, BK ;

Thomas, MG ;

Walsh, CT .

CHEMISTRY & BIOLOGY, 2000, 7 (12) :931-942

[8]

LI TL, UNPUB CHEM COMMUN

[9] EXPRESSION OF SPINACH GLYCOLATE OXIDASE IN SACCHAROMYCES-CEREVISIAE - PURIFICATION AND CHARACTERIZATION [J].

MACHEROUX, P ;

MASSEY, V ;

THIELE, DJ ;

VOLOKITA, M .

BIOCHEMISTRY, 1991, 30 (18) :4612-4619

[10]

Sandercock AM, 2001, CHEM COMMUN, P1252, DOI 10.1039/b103668h

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