CpGassoc: an R function for analysis of DNA methylation microarray data

被引:164
作者
Barfield, Richard T. [1 ]
Kilaru, Varun [2 ]
Smith, Alicia K. [2 ]
Conneely, Karen N. [1 ,3 ]
机构
[1] Emory Univ, Sch Publ Hlth, Dept Bioinformat & Biostat, Atlanta, GA 30322 USA
[2] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
[3] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA
关键词
DISCOVERY; ASSOCIATE;
D O I
10.1093/bioinformatics/bts124
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
With the increasing availability of high-density methylation microarrays, there has been growing interest in analysis of DNA methylation data. We have developed CpGassoc, an R package that can efficiently perform the statistical analysis needed for increasingly large methylation datasets. CpGassoc is a modular, expandable package with functions to perform rapid analyses of DNA methylation data via fixed or mixed effects models, to perform basic quality control, to carry out permutation tests, and to display results via an array of publication-quality plots.
引用
收藏
页码:1280 / 1281
页数:2
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