Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle

被引：44

作者：

Zubarev, Dmitry Yu ^{[1
]}

Rappoport, Dmitrij ^{[1
]}

Aspuru-Guzik, Alan ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

美国国家科学基金会;

关键词：

CITRIC-ACID; CARBON FIXATION; KREBS CYCLE; GLYOXYLATE; CHEMISTRY; ORIGIN;

D O I：

10.1038/srep08009

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rTCA cycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investigations of the origin of the common metabolic core should be significantly extended.

引用

页数：7

共 24 条

[1]

[Anonymous], 1966, J CHEM INFORM COMPUT, V28, P31

[2] Design and analysis of synthetic carbon fixation pathways [J].

Bar-Even, Arren ;

Noor, Elad ;

Lewis, Nathan E. ;

Milo, Ron .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (19) :8889-8894

[3] A REVERSE KREBS CYCLE IN PHOTOSYNTHESIS - CONSENSUS AT LAST [J].

BUCHANAN, BB ;

ARNON, DI .

PHOTOSYNTHESIS RESEARCH, 1990, 24 (01) :47-53

[4] Production of Tartrates by Cyanide-Mediated Dimerization of Glyoxylate: A Potential Abiotic Pathway to the Citric Acid Cycle [J].

Butch, Christopher ;

Cope, Elizabeth D. ;

Pollet, Pamela ;

Gelbaum, Leslie ;

Krishnamurthy, Ramanarayanan ;

Liotta, Charles L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (36) :13440-13445

[5] Detection and formation scenario of citric acid, pyruvic acid, and other possible metabolism precursors in carbonaceous meteorites [J].

Cooper, George ;

Reed, Chris ;

Dang Nguyen ;

Carter, Malika ;

Wang, Yi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (34) :14015-14020

[6] ORIGIN OF GENETIC CODE [J].

CRICK, FHC .

JOURNAL OF MOLECULAR BIOLOGY, 1968, 38 (03) :367-&

[7] Photo-production of lactate from glyoxylate: how minerals can facilitate energy storage in a prebiotic world [J].

Guzman, Marcelo I. ;

Martin, Scot T. .

CHEMICAL COMMUNICATIONS, 2010, 46 (13) :2265-2267

[8] Beyond the Calvin Cycle: Autotrophic Carbon Fixation in the Ocean [J].

Huegler, Michael ;

Sievert, Stefan M. .

ANNUAL REVIEW OF MARINE SCIENCE, VOL 3, 2011, 3 :261-289

[9] COSMO - A NEW APPROACH TO DIELECTRIC SCREENING IN SOLVENTS WITH EXPLICIT EXPRESSIONS FOR THE SCREENING ENERGY AND ITS GRADIENT [J].

KLAMT, A ;

SCHUURMANN, G .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1993, (05) :799-805

[10] The origin of intermediary metabolism [J].

Morowitz, HJ ;

Kostelnik, JD ;

Yang, J ;

Cody, GD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7704-7708

← 1 2 3 →