Composite Hydrogels with Tunable Anisotropic Morphologies and Mechanical Properties

被引：247

作者：

Chau, Mokit ^{[1
]}

De France, Kevin J. ^{[2
]}

Kopera, Bernd ^{[1
,3
]}

Machado, Vanessa R. ^{[1
]}

Rosenfeldt, Sabine ^{[3
]}

Reyes, Laura ^{[1
]}

Chan, Katelyn J. W. ^{[2
]}

Foerster, Stephan ^{[3
]}

Cranston, Emily D. ^{[2
]}

Hoare, Todd ^{[2
,4
]}

Kumacheva, Eugenia ^{[1
,5
,6
]}

机构：

[1] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada

[2] McMaster Univ, Dept Chem Engn, 1280 Main St W, Hamilton, ON L8S 4L7, Canada

[3] Univ Bayreuth, Phys Chem 1, 30 Univ Str, D-95440 Bayreuth, Germany

[4] McMaster Univ, Sch Biomed Engn, 1280 Main St West, Hamilton, ON L8S 4L7, Canada

[5] Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada

[6] Univ Toronto, Inst Biomat & Biomed Engn, 4 Taddle Creek Rd, Toronto, ON M5S 3G9, Canada

来源：

CHEMISTRY OF MATERIALS | 2016年 / 28卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

NANOCOMPOSITE HYDROGELS; CELLULOSE NANOCRYSTALS; RESPONSIVE HYDROGELS; HYBRID HYDROGELS; CELL ALIGNMENT; PROGRESS; POLYMERIZATION; CONDUCTIVITY; SCAFFOLDS; NETWORK;

D O I：

10.1021/acs.chemmater.6b00792

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Fabrication of anisotropic hydrogels exhibiting direction-dependent structure and properties has attracted great interest in biomimicking, tissue engineering, and bioseparation. Herein, we report a freeze-casting-based fabrication of structurally and mechanically anisotropic aerogels and hydrogels composed of hydrazone cross-linked poly(oligoethylene glycol methacrylate) (POEGMA) and cellulose nanocrystals (CNCs). We show that, by controlling the composition of the CNC/POEGMA dispersion and the freeze-casting temperature, aerogels with fibrillar, columnar, or lamellar morphologies can be produced. Small-angle X-ray scattering experiments show that the anisotropy of the structure originates from the alignment of the mesostructures, rather than the CNC building blocks. The composite hydrogels show high structural and mechanical integrity and a strong variation in Young's moduli in orthogonal directions. The controllable morphology and hydrogel anisotropy, coupled with hydrazone cross-linking and biocompatibility of CNCs and POEGMA, provide a versatile platform for the preparation of anisotropic hydrogels.

引用

页码：3406 / 3415

页数：10

共 73 条

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Hybrid hydrogels containing vertically aligned carbon nanotubes with anisotropic electrical conductivity for muscle myofiber fabrication [J].