PTPN22:: Its role in SLE and autoimmunity

被引：81

作者：

Chung, Sharon A. ^{[1
]}

Criswell, Lindsey A. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA USA

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 08期

关键词：

SLE; PTPN22; autoimmunity; genetics;

D O I：

10.1080/08916930701510848

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.

引用

页码：582 / 590

页数：9

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