Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

被引：955

作者：

Fernandez-Marcos, Pablo J. ^{[1
]}

Auwerx, Johan ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, Lausanne, Switzerland

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2011年 / 93卷 / 04期

基金：

欧洲研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; FATTY-ACID OXIDATION; TRANSCRIPTIONAL COACTIVATOR; RECEPTOR-GAMMA; NUCLEAR RECEPTORS; SKELETAL-MUSCLE; HEPATIC GLUCONEOGENESIS; GENE-EXPRESSION; ENERGY-EXPENDITURE; BROWN FAT;

D O I：

10.3945/ajcn.110.001917

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Mechanisms responsible for energy management in the cell and in the whole organism require a complex network of transcription factors and cofactors. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) has emerged as a master regulator of mitochondrial biogenesis and function, thus becoming a crucial metabolic node. We present an overview of the mechanisms by which PGC-1 alpha is regulated, including the transcriptional regulation of PGC-1 alpha expression and the fine-tuning of its final activity via posttranslational modifications. Am J Clin Nutr 2011; 93 (suppl):884S-90S.

引用

页码：884S / 890S

页数：7

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