Antibacterial tests of bismuth(III)-quinolone (ciprofloxacin, cf) compounds against Helicobacter pylori and some other bacteria.: Crystal structure of (cfH2)2[Bi2Cl10]•4H2O

The antibacterial tests of two bismuth(III)-ciprofloxacin (cf) compounds against Helicobacter pylori (H. pylori) and some other bacteria were performed. The results have shown that the activity of both compounds is comparable to that of ciprofloxacin hydrochloride. The crystal structure of (CfH2)(2)[Bi2Cl10]. 4H(2)O (cfH(2) = doubly protonated molecule of cf) is presented and discussed. The compound was isolated from acidic medium where quinolone is protonated and thus no bonding between quinolone and bismuth was observed. The bismuth(III) ions are coordinated by chloride ions forming dinuclear [Bi2Cl10](4-) anions. The charge of this ion is compensated with protonated quinolone molecules (ionic interactions). (C) 1998 Elsevier Science Inc. All rights reserved.