Modulation of apoptosis in human lymphocytes by adenosine analogues

被引：2

作者：

Barbieri, D

Franceschi, C

Camaioni, E

Costanzi, S

Vittori, S

Volpini, R

Cristalli, G

机构：

[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

[2] Univ Modena, Dept Biomed Sci, Sect Gen Pathol, I-41100 Modena, Italy

[3] INRCA, Italian Natl Res Ctr Aging, Ancona, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(98)00452-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We previously described that 2-chloroadenosine (2CA) and 2-chloro-2'-deoxyadenosine (2CdA) induced apoptosis in human peripheral blood mononuclear cells (PBMC). In this study we tested different adenosine analogues on PBMC and we found that the modifications introduced in the 2CA structure prevented the molecule from exerting its apoptotic effect. On the other hand, substitutions on 2CdA are tolerated, although with a significant decrease in activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2533 / 2538

页数：6

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