Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm

被引:38
作者
Cardillo, C
Kilcoyne, CM
Nambi, SS
Cannon, RO
Quon, MJ
Panza, JA
机构
[1] NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA
[2] NHLBI, Hypertens Endocrine Branch, NIH, Bethesda, MD 20892 USA
关键词
insulin; vasodilation; glucose; nitric oxide; L-NMMA;
D O I
10.1161/01.HYP.32.4.740
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Insulin-mediated vasodilation has been proposed as an important determinant of whole-body insulin-stimulated glucose disposal. However, it is not clear whether the vasodilator effect of insulin results from a direct action of the hormone or whether alternative mechanisms are involved. To better characterize the mechanism of insulin-mediated vasorelaxation, we compared forearm blood flow (FBF) responses to local (intra-arterial) and systemic (intravenous, euglycemic clamp) hyperinsulinemia in 10 healthy lean subjects using venous occlusion plethysmography. In addition, we assessed the effect of nitric oxide (NO) synthase inhibition by N-G-monomethyl-L-arginine (L-NMMA) on the vasodilator and metabolic responses to hyperinsulinemia. Similar forearm concentrations of insulin were achieved during local and systemic infusion (231+/-39 versus 265+/-22 mu U/mL; P=0.54). Of note, FBF did not change significantly in response to local hyperinsulinemia (from 2.6+/-0.3 to 2.4+/-0.3 mt . min(-1) . dL(-1); P=0.50). In contrast, systemic hyperinsulinemia caused a 52% increase in FBF (from 2.5+/-0.2 to 3.8+/-0.5 mL . min(-1) . dL(-1); P<0.004), which was reversed by L-NMMA (FBF decreased from 3.8+/-0.5 to 2.3+/-0.2 mL . min(-1) . dL(-1); P=0.004). We conclude that systemic, but not local, hyperinsulinemia induces vasodilation in the forearm. Our findings suggest that insulin-mediated vasodilation is not due solely to a direct stimulatory effect of insulin but involves additional mechanisms activated only during systemic hyperinsulinemia.
引用
收藏
页码:740 / 745
页数:6
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