Targeting the Hedgehog Pathway in Cancer: Can the Spines Be Smoothened?

被引：9

作者：

Ailles, Laurie ^{[1
]}

Siu, Lillian L. ^{[1
]}

机构：

[1] Univ Toronto, Princess Margaret Hosp, Ontario Canc Inst, Drug Dev Program, Toronto, ON M5G 2M9, Canada

来源：

CLINICAL CANCER RESEARCH | 2011年 / 17卷 / 08期

关键词：

CHEMOTHERAPY; INHIBITION; RESISTANCE; CELLS;

D O I：

10.1158/1078-0432.CCR-11-0211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Aberrant Hedgehog (Hh) pathway signaling has been suggested to play a role in the development of multiple solid tumors and hematologic malignancies. GDC-0449 is a novel first-in-human, first-in-class smoothened (SMO) inhibitor, which has completed its phase I evaluation and achieved proof of concept in tumors with Hh pathway mutations. © 2011 American Association for Cancer Research.

引用

页码：2071 / 2073

页数：3

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