Identification and characterization of two polymorphic Ya5 Alu repeats

被引：16

作者：

Arcot, SS

DeAngelis, MN

Sherry, ST

Adamson, AW

Lamerdin, JE

Deininger, PL

Carrano, AV

Batzer, MA

机构：

[1] Louisiana State Univ, Med Ctr, Dept Pathol, New Orleans, LA 70112 USA

[2] Univ Calif Lawrence Livermore Natl Lab, Ctr Human Genome, Biol & Biotechnol Res Program, Livermore, CA 94551 USA

[3] Louisiana State Univ, Med Ctr, Neurosci Ctr Excellence, Stanley S Scott Canc Ctr,Dept Biometry & Genet, New Orleans, LA 70112 USA

[4] Louisiana State Univ, Med Ctr, Neurosci Ctr Excellence, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA

[5] Alton Ochsner Med Fdn & Ochsner Clin, Mol Genet Lab, New Orleans, LA 70121 USA

来源：

MUTATION RESEARCH-GENOMICS | 1997年 / 382卷 / 1-2期

关键词：

genetic variation; mobile elements; insertion polymorphism; human-specific;

D O I：

10.1016/S1383-5726(97)00002-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new polymorphic Alu elements (HS2.25 and HS4.14) belonging to the young (Ya5/8) subfamily of human-specific Alu repeats have been identified. DNA sequence analysis of both Alu repeats revealed that each Alu repeat had a long 3'-oligo-dA-rich tail (41 and 52 nucleotides in length) and a low level of random mutations. HS2.25 and HS4.14 were flanked by short precise direct repeats of 8 and 14 nucleotides in length, respectively. HS2.25 was located on human chromosome 13, and HS4.14 on chromosome 1. Both Alu elements were absent from the orthologous positions within the genomes of non-human primates, and were highly polymorphic in a survey of twelve geographically diverse human groups. (C) 1997 Elsevier Science B.V.

引用

页码：5 / 11

页数：7

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