Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers

被引：216

作者：

Anitua, Eduardo ^{[1
]}

Aguirre, Jose J. ^{[1
]}

Algorta, Jaime ^{[2
]}

Ayerdi, Eduardo ^{[3
]}

Cabezas, Ana I. ^{[4
]}

Orive, Gorka ^{[1
]}

Andia, Isabel ^{[1
]}

机构：

[1] Inst Biotechnol, Vitoria, Spain

[2] Hosp Txagorritxu, Fdn LEIA, Vitoria, Spain

[3] Hosp Txagorritxu, Serv Traumatol, Vitoria, Spain

[4] Hosp Txagorritxu, Serv Vasc Surg, Vitoria, Spain

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2008年 / 84B卷 / 02期

关键词：

chronic cutaneous ulcers; platelet; growth factors; PRGF; randomized trial;

D O I：

10.1002/jbm.b.30886

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF-AB, TGF-beta 1, IGF-I, HGF, VEGF-A, and EGF. In this article, we have characterized the PRGF preparation and designed a randomized open-label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous Ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94% +/- 22.25% whereas it was 21.48% +/- 33.56% in the control group (P < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal. (C) 2007 Wiley Periodicals, Inc.

引用

页码：415 / 421

页数：7

共 32 条

[1] Autologous fibrin matrices: A potential source of biological mediators that modulate tendon cell activities [J].