Stimulation of bone formation in vivo by insulin-like growth factor-II in rats

被引：15

作者：

Ishibe, M

Ishibashi, T

Kaneda, K

Koda, T

Rosier, RN

Puzas, JE

机构：

[1] Sapporo Hosp, NTT, Dept Orthopaed Surg, Sapporo, Hokkaido 060, Japan

[2] Hokkaido Univ, Sch Med, Dept Biochem, Sapporo, Hokkaido 060, Japan

[3] Hokkaido Univ, Sch Med, Dept Orthopaed, Sapporo, Hokkaido 060, Japan

[4] Hokkaido Univ, Sch Med, Inst Immunol Sci, Sapporo, Hokkaido 060, Japan

[5] Univ Rochester, Sch Med & Dent, Dept Orthopaed, Rochester, NY 14620 USA

来源：

CALCIFIED TISSUE INTERNATIONAL | 1998年 / 63卷 / 01期

关键词：

insulin-like growth factor-II; bone formation; bone mineral density;

D O I：

10.1007/s002239900486

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-like growth factor-II (IGF-II) plays an important role in skeletal remodeling, however, little is known about its effect on bone formation in vivo. In our study of the stimulation of bone formation in vivo by IGF-II we injected recombinant human IGF-II into the parietal bones of neonatal rats once a day for 12 days. The bone mineral density measured by dual energy X-ray absorptiometry and the thickness of IGF-II-injected parietal bones increased in a dose-dependent manner. The layers of osteoblasts were observed along the IGF-II-injected side.

引用

页码：36 / 38

页数：3

共 20 条

[1] INSULIN-LIKE GROWTH-FACTORS INHIBIT INTERSTITIAL COLLAGENASE SYNTHESIS IN BONE CELL-CULTURES [J].