Assessment of spontaneous fluctuations of viral load in untreated patients with chronic hepatitis C by two standardized quantitation methods:: Branched DNA and Amplicor monitor

被引：27

作者：

Halfon, P

Bourlière, M

Halimi, G

Khiri, H

Bertezene, P

Portal, I

Bota-Fridlund, D

Gauthier, AP

Jullien, M

Feryn, JM

Gerolami, V

Cartouzou, G

机构：

[1] Hop Concept, Alphabio Lab, Marseille, France

[2] Hop Concept, Dept Biochem, Marseille, France

[3] Hop Concept, Dept Hepatogastroenterol, Marseille, France

[4] Hop St Joseph, Dept Hepatogastroenterol, Marseille, France

[5] INSERM, U315, F-13258 Marseille, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1998年 / 36卷 / 07期

关键词：

D O I：

10.1128/JCM.36.7.2073-2075.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quantitation of hepatitis C virus (HCV) RNA in serum has been used to predict and monitor the efficacy of interferon therapy in chronic HCV infection. We prospectively studied the fluctuation of viremia by a longitudinal follow-up of HCV RNA levels for 2 months in six untreated patients. Spontaneous fluctuations of HCV RNA ranged from 2.8- to 5.7-fold with branched DNA assay and from 2.9- to 5.6-fold with Monitor. These large spontaneous fluctuations (up to 0.75 log), observed daily, weekly, and monthly, raise doubt about the clinical value of a single assessment of pretherapeutic viremia.

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页码：2073 / 2075

页数：3

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