Magnetization transfer contrast imaging in Niemann Pick type C mouse liver

被引:16
作者
Guo, JY
Erickson, R
Trouard, T
Galons, JP
Gillies, R
机构
[1] Univ Arizona, Arizona Canc Ctr, Coll Med, Physiol Sci Program, Tucson, AZ 85724 USA
[2] Univ Arizona, Coll Med, Dept Pediat, Sect Med & Mol Genet, Tucson, AZ USA
[3] Univ Arizona, Coll Med, Biomed Engn Program, Tucson, AZ USA
[4] Univ Arizona, Coll Med, Dept Radiol, Tucson, AZ USA
[5] Univ Arizona, Coll Med, Dept Biochem & Mol Biophys, Tucson, AZ USA
关键词
magnetization transfer; Niemann Pick type C disease; cholesterol metabolism; liver fibrosis; collagen deposition;
D O I
10.1002/jmri.10404
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To investigate livers of mice afflicted with Niemann Pick type C (NP-C) disease using magnetization transfer contrast (MTC) imaging and to test the hypothesis that the MT ratio reproducibly changes during disease progression. Background: NP-C is a heritable defect of lipid metabolism that results in the accumulation of unesterified cholesterol and gangliosides in virtually all cells. Symptoms predominate in brain and liver, which have high endogenous rates of lipid turnover. It is fatal to children, usually early in the second decade of life. Previous work has shown that the efficiency of magnetization transfer (MT) can be affected by cholesterol and collagen in tissues. The MT ratio (MTR) was calculated and compared during growth and therapy of diseased and control mice. Results: Significant differences in the MTR were observed between livers of diseased and control mice. These ratios were consistent with collagen deposition associated with fibrosis, and not the accumulation of unesterified cholesterol in this organ. Conclusion: These results indicate that MTC imaging may have clinical potential for monitoring progression and therapy in NP-C disease.
引用
收藏
页码:321 / 327
页数:7
相关论文
共 21 条
[1]  
AISEN AM, 1994, MAGNET RESON MED, V31, P511
[2]   NIEMANN-PICK DISEASE TYPE-C AND TYPE-D [J].
BRADY, RO ;
FILLINGKATZ, MR ;
BARTON, NW ;
PENTCHEV, PG .
NEUROLOGIC CLINICS, 1989, 7 (01) :75-88
[3]   Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease [J].
Camargo, F ;
Erickson, RP ;
Garver, WS ;
Hossain, GS ;
Carbone, PN ;
Heidenreich, RA ;
Blanchard, J .
LIFE SCIENCES, 2001, 70 (02) :131-142
[4]   Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis [J].
Carstea, ED ;
Morris, JA ;
Coleman, KG ;
Loftus, SK ;
Zhang, D ;
Cummings, C ;
Gu, J ;
Rosenfeld, MA ;
Pavan, WJ ;
Krizman, DB ;
Nagle, J ;
Polymeropoulos, MH ;
Sturley, SL ;
Ioannou, YA ;
Higgins, ME ;
Comly, M ;
Cooney, A ;
Brown, A ;
Kaneski, CR ;
BlanchetteMackie, EJ ;
Dwyer, NK ;
Neufeld, EB ;
Chang, TY ;
Liscum, L ;
Strauss, JF ;
Ohno, K ;
Zeigler, M ;
Carmi, R ;
Sokol, J ;
Markie, D ;
ONeill, RR ;
vanDiggelen, OP ;
Elleder, M ;
Patterson, MC ;
Brady, RO ;
Vanier, MT ;
Pentchev, PG ;
Tagle, DA .
SCIENCE, 1997, 277 (5323) :228-231
[5]   LIPID BILAYER AND WATER PROTON MAGNETIZATION TRANSFER - EFFECT OF CHOLESTEROL [J].
FRALIX, TA ;
CECKLER, TL ;
WOLFF, SD ;
SIMON, SA ;
BALABAN, RS .
MAGNETIC RESONANCE IN MEDICINE, 1991, 18 (01) :214-223
[6]  
Gray P., 1975, MICROTOMISTS FORMULA
[7]  
HEIDER JG, 1978, J LIPID RES, V19, P514
[8]   QUANTITATIVE INTERPRETATION OF MAGNETIZATION-TRANSFER [J].
HENKELMAN, RM ;
HUANG, XM ;
XIANG, QS ;
STANISZ, GJ ;
SWANSON, SD ;
BRONSKILL, MJ .
MAGNETIC RESONANCE IN MEDICINE, 1993, 29 (06) :759-766
[9]   ANALYSIS OF WATER-MACROMOLECULE PROTON MAGNETIZATION TRANSFER IN ARTICULAR-CARTILAGE [J].
KIM, DK ;
CECKLER, TL ;
HASCALL, VC ;
CALABRO, A ;
BALABAN, RS .
MAGNETIC RESONANCE IN MEDICINE, 1993, 29 (02) :211-215
[10]   RELAXIVITY AND MAGNETIZATION-TRANSFER OF WHITE-MATTER LIPIDS AT MR-IMAGING - IMPORTANCE OF CEREBROSIDES AND PH [J].
KUCHARCZYK, W ;
MACDONALD, PM ;
STANISZ, GJ ;
HENKELMAN, RM .
RADIOLOGY, 1994, 192 (02) :521-529