Osmotic shock and the strength of viral capsids

被引:81
作者
Cordova, A
Deserno, M
Gelbart, WM
Ben-Shaul, A
机构
[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[2] Hebrew Univ Jerusalem, Dept Chem Phys, IL-91904 Jerusalem, Israel
[3] Hebrew Univ Jerusalem, Fritz Haber Inst, IL-91904 Jerusalem, Israel
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0006-3495(03)74455-5
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Osmotic shock is a familiar means for rupturing viral capsids and exposing their genomes intact. The necessary conditions for providing this shock involve incubation in high-concentration salt solutions, and lower permeability of the capsids to salt ions than to water molecules. We discuss here how values of the capsid strength can be inferred from calculations of the osmotic pressure differences associated with measured values of the critical concentration of incubation solution.
引用
收藏
页码:70 / 74
页数:5
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