L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease

被引：400

作者：

Cools, R

Barker, RA

Sahakian, BJ

Robbins, TW

机构：

[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB3 9DF, England

[2] Univ Cambridge, Cambridge Ctr Brain Repair, Dept Neurol, Cambridge, England

[3] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge, England

来源：

NEUROPSYCHOLOGIA | 2003年 / 41卷 / 11期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

task-switching; decision-making; dopamine; prefrontal cortex; basal ganglia;

D O I：

10.1016/S0028-3932(03)00117-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In the current study we investigated the role of dopamine in attentional and socio-emotional functioning by examining effects of withdrawing dopaminergic medication in patients with Parkinson's disease (PD). Patients 'on' medication exhibited abnormal betting strategies on a task of decision-making, reflecting impulsive behaviour and/or delay aversion, whilst the same patients 'off' medication exhibited abnormally increased switch costs when switching between two tasks, reflecting attentional inflexibility. Hence, these data replicate and extend previous findings that dopaminergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of dopamine function in underlying cortico-striatal circuitry. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1431 / 1441

页数：11

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