Studies in marine macrolide synthesis: Construction of a 24-membered macrocyclic intermediate for aplyronine A

被引：31

作者：

Paterson, I ^{[1
]}

Woodrow, MD ^{[1
]}

Cowden, CJ ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(98)01192-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-1-C-27 macrolide 2, which contains 11 stereocentres and 4 double bonds, was constructed by an efficient 3-component coupling followed by a macrolactonisation/isomerization sequence. Key steps were the alkylation of the dianion of phosphonate 5 with iodide 7 and a Ba(OH)(2)-mediated HWE reaction with 6 to install the trisubstituted double bond. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：6041 / 6044

页数：4

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