Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism

被引：22

作者：

Chu, M ^{[1
]}

Mierzwa, R ^{[1
]}

Xu, L ^{[1
]}

Yang, SW ^{[1
]}

He, L ^{[1
]}

Patel, M ^{[1
]}

Stafford, J ^{[1
]}

Macinga, D ^{[1
]}

Black, T ^{[1
]}

Chan, TM ^{[1
]}

Gullo, V ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 21期

关键词：

D O I：

10.1016/j.bmcl.2003.07.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel acyl carrier protein synthase inhibitor, Sch 538415 (1), was isolated from an unidentified bacterial microbe. Structure elucidation of 1 was accomplished based on analysis of spectroscopic data including UV, MS and 2D-NMR spectra. Compound I exhibited inhibitory activity in the acyl carrier protein synthase (AcpS) assay with an IC50 value of 4.19 muM and showed antibacterial activity against Staphylococcus aureus in the agar diffusion assay. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3827 / 3829

页数：3

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