How Saccharomyces cerevisiae copes with toxic metals and metalloids

被引：229

作者：

Wysocki, Robert ^{[2
]}

Tamas, Markus J. ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Cell & Mol Biol Microbiol, S-40530 Gothenburg, Sweden

[2] Univ Wroclaw, Inst Genet & Microbiol, PL-50138 Wroclaw, Poland

来源：

FEMS MICROBIOLOGY REVIEWS | 2010年 / 34卷 / 06期

基金：

瑞典研究理事会;

关键词：

arsenic; cadmium; chromium; selenium; metal toxicity; metal detoxification; ACTIVATED PROTEIN-KINASE; OXIDATIVE-STRESS-RESPONSE; BINDING CASSETTE TRANSPORTER; YAP1 TRANSCRIPTION FACTOR; ZRT1 ZINC TRANSPORTER; UBIQUITIN-DEPENDENT DEGRADATION; RESISTANCE-ASSOCIATED PROTEIN; INORGANIC-PHOSPHATE UPTAKE; PUTATIVE MEMBRANE-PROTEIN; PATHOGEN CANDIDA-ALBICANS;

D O I：

10.1111/j.1574-6976.2010.00217.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Toxic metals and metalloids are widespread in nature and can locally reach fairly high concentrations. To ensure cellular protection and survival in such environments, all organisms possess systems to evade toxicity and acquire tolerance. This review provides an overview of the molecular mechanisms that contribute to metal toxicity, detoxification and tolerance acquisition in budding yeast Saccharomyces cerevisiae. We mainly focus on the metals/metalloids arsenic, cadmium, antimony, mercury, chromium and selenium, and emphasize recent findings on sensing and signalling mechanisms and on the regulation of tolerance and detoxification systems that safeguard cellular and genetic integrity.

引用

页码：925 / 951

页数：27

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