Emergence of HIV-1 mutated strains after interruption of highly active antiretroviral therapy in chronically infected patients

被引：11

作者：

Daniel, N ^{[1
]}

Schneider, V

Pialoux, G

Krivine, A

Grabar, S

Nguyen, TH

Girard, PM

Rozenbaum, W

Salmon, D

机构：

[1] Cochin Hosp, Dept Internal Med, Paris, France

[2] Cochin Hosp, Dept Virol, Paris, France

[3] Cochin Hosp, Dept Biostat, Paris, France

[4] Univ Paris 05, CNRS, UMR 8104, INSERM,U567,Dept Immunol, Paris, France

[5] Tenon Hosp, Dept Virol, Paris, France

[6] Tenon Hosp, Dept Infect Dis, Paris, France

[7] Hop St Antoine, Dept Infect Dis, Paris, France

来源：

AIDS | 2003年 / 17卷 / 14期

关键词：

D O I：

10.1097/00002030-200309260-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the emergence of HIV-1 mutated strains after long-term viral suppression in four patients who interrupted highly active antiretroviral therapy (HAART). In two cases, mutations pre-existed in proviral DNA before HAART interruption. All mutations were associated with resistance to nucleoside reverse transcriptase inhibitors, and three of the four patients had prolonged periods of monotherapy or dual therapy. Resistant strains may re-emerge rapidly even in patients harbouring a majority of wild-type virus in proviral DNA before treatment interruption.

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页码：2126 / 2129

页数：4

相关论文

共 17 条

[1] Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression [J].

Appay, V ;

Hansasuta, P ;

Sutton, J ;

Schrier, RD ;

Wong, JK ;

Furtado, M ;

Havlir, DV ;

Wolinsky, SM ;

McMichael, AJ ;

Richman, DD ;

Rowland-Jones, SL ;

Spinha, CA .

AIDS, 2002, 16 (02) :161-170

[2] Kinetics of HIV-1 RNA and resistance-associated mutations after cessation of antiretroviral combination therapy [J].

Birk, M ;

Svedhem, V ;

Sönnerborg, A .

AIDS, 2001, 15 (11) :1359-1368

[3] Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infection [J].

Carcelain, G ;

Tubiana, R ;

Samri, A ;

Calvez, V ;

Delaugerre, C ;

Agut, H ;

Katlama, C ;

Autran, B .

JOURNAL OF VIROLOGY, 2001, 75 (01) :234-241

[4] Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy [J].

Chun, TW ;

Davey, RT ;

Ostrowski, M ;

Justement, JS ;

Engel, D ;

Mullins, JI ;

Fauci, AS .

NATURE MEDICINE, 2000, 6 (07) :757-761

[5] Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid [J].

Cunningham, PH ;

Smith, DG ;

Satchell, C ;

Cooper, DA ;

Brew, B .

AIDS, 2000, 14 (13) :1949-1954

[6] Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. [J].

Deeks, SG ;

Wrin, T ;

Liegler, T ;

Hoh, R ;

Hayden, M ;

Barbour, JD ;

Hellmann, NS ;

Petropoulos, CJ ;

McCune, JM ;

Hellerstein, MK ;

Grant, RM .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (07) :472-480

[7] Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy [J].

Finzi, D ;

Hermankova, M ;

Pierson, T ;

Carruth, LM ;

Buck, C ;

Chaisson, RE ;

Quinn, TC ;

Chadwick, K ;

Margolick, J ;

Brookmeyer, R ;

Gallant, J ;

Markowitz, M ;

Ho, DD ;

Richman, DD ;

Siliciano, RF .

SCIENCE, 1997, 278 (5341) :1295-1300

[8] Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy [J].

García, F ;

Plana, M ;

Vidal, C ;

Cruceta, A ;

O'Brien, WA ;

Pantaleo, G ;

Pumarola, T ;

Gallart, T ;

Miró, JM ;

Gatell, JM .

AIDS, 1999, 13 (11) :F79-F86

[9] The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection [J].

García, F ;

Plana, M ;

Ortiz, GM ;

Bonhoeffer, S ;

Soriano, A ;

Vidal, C ;

Cruceta, A ;

Arnedo, M ;

Gil, C ;

Pantaleo, G ;

Pumarola, T ;

Gallart, T ;

Nixon, DF ;

Miró, JM ;

Gatell, JM .

AIDS, 2001, 15 (09) :F29-F40

[10] Antiretroviral drug resistance testing in adult HIV-1 infection -: Recommendations of an International AIDS Society-USA panel [J].

Hirsch, MS ;

Brun-Vézinet, F ;

D'Aquila, RT ;

Hammer, SM ;

Johnson, VA ;

Kuritzkes, DR ;

Loveday, C ;

Mellors, JW ;

Clotet, B ;

Conway, B ;

Demeter, LM ;

Vella, S ;

Jacobsen, DM ;

Richman, DD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (18) :2417-2426