Lupeol is the cytotoxic principle in the leaf extract of Dendropanax cf. querceti

被引：46

作者：

Moriarity, DM ^{[1
]}

Huang, J

Yancey, CA

Zhang, P

Setzer, WN

Lawton, RO

Bates, RB

Caldera, S

机构：

[1] Univ Alabama, Dept Biol Sci, Huntsville, AL 35899 USA

[2] Univ Alabama, Dept Chem, Huntsville, AL 35899 USA

[3] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

PLANTA MEDICA | 1998年 / 64卷 / 04期

关键词：

D O I：

10.1055/s-2006-957454

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The crude ethanol extract from the leaves of Dendroponax cf. querceti (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-GZ, A-431, and H-411E tumor cell lines. The active component has been isolated by activity-directed separation and identified by H-1-and C-13-NMR spectroscopy as the triterpene lupeol. The mechanism of cytotoxic activity of lupeol has been determined to be inhibition of topoisomerase II.

引用

页码：370 / 372

页数：3

共 18 条

[1]

BIRNBOIM HC, 1979, NUCLEIC ACIDS RES, V7, P1513

[2]

Duke JamesA., 2002, Handbook of Medicinal Herbs, VSecond

[3] MTT COLORIMETRIC ASSAY FOR TESTING MACROPHAGE CYTOTOXIC ACTIVITY INVITRO [J].

FERRARI, M ;

FORNASIERO, MC ;

ISETTA, AM .

JOURNAL OF IMMUNOLOGICAL METHODS, 1990, 131 (02) :165-172

[4]

HABER W. A., 1991, BRENESIA, V34, P63

[5]

Ipsen J, 1970, BANCROFTS INTRO BIOS

[6]

KAHLOS K, 1989, Fitoterapia, V60, P166

[7]

KAPELLE M, 1991, BRENESIA, V34, P121

[8] STUDIES ON INHIBITORS OF SKIN-TUMOR PROMOTION .1. INHIBITORY EFFECTS OF TRITERPENES FROM EUPTELEA-POLYANDRA ON EPSTEIN-BARR VIRUS-ACTIVATION [J].

KONOSHIMA, T ;

TAKASAKI, M ;

KOZUKA, M ;

TOKUDA, H .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (06) :1167-1170

[9]

Lawrence GHM., 1951, Taxonomy of Vascular Plants

[10]

LIU R, 1990, ZHONGCAOYAO, V21, P242

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