Simultaneous spectrophotometric determination of diuretics by using multivariate calibration methods

被引：27

作者：

Luis, ML ^{[1
]}

Fraga, JMG ^{[1
]}

Jiménez, F ^{[1
]}

Jiménez, AI ^{[1
]}

Arias, JJ ^{[1
]}

机构：

[1] Univ la Laguna, Fac Quim, Dept Quim Analit Nutr & Bromatol, E-38204 San Cristobal de la Laguna, Tenerife, Spain

来源：

TALANTA | 2001年 / 53卷 / 04期

关键词：

wavelength range selection; partial least-squares; diuretics;

D O I：

10.1016/S0039-9140(00)00538-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The wavelength range and number of factors used in partial least-squares (PLS) calibration for the resolution of the dihydralazine (DHZ)-hydrochlorothiazide (HCT) binary mixture and the dihydralazine-hpdrochlorothiazide-reserpine ternary mixture were optimized in terms of the relative standard error (R.S.E.) and relative mean standard error (R.M.S.E.). Under the optimum conditions thus established, synthetic mixtures of the analytes can be resolved with errors and relative standard deviations (R.S.D) less than 4.5 and 1.0%, respectively. The ensuing method, which was validated by comparison with high performance liquid chromatography (HPLC), also gives good results with real samples (pharmaceutical preparations). (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：761 / 770

页数：10

共 18 条

[1] DIODE-ARRAY DETECTORS IN FLOW-INJECTION ANALYSIS - MIXTURE RESOLUTION BY MULTI-WAVELENGTH ANALYSIS [J].