Geminiviruses and RNA silencing

被引:122
作者
Vanitharani, R [1 ]
Chellappan, P [1 ]
Fauquet, CM [1 ]
机构
[1] Donald Danforth Plant Sci Ctr, Int Lab Trop Agr Biotechnol, St Louis, MO 63132 USA
关键词
D O I
10.1016/j.tplants.2005.01.005
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Geminiviruses are single-stranded circular DNA viruses that cause economically significant diseases in a wide range of crop plants worldwide. In plants, post-transcriptional gene silencing (PTGS) acts as a natural antiviral defense system and plays a role in genome maintenance and development. During the past decade there has been considerable evidence of PTGS suppression by viruses, which is often required to establish infection in plants. In particular, nuclear-replicating geminiviruses, which have no double-stranded RNA phase in their replication cycle, can induce and suppress the PTGS and become targets for PTGS. Here, we summarize recent developments in determining how these viruses trigger PTGS and how they suppress the induced PTGS, as well as how we can use the system to control these viruses in plants better and manipulate the system to study functional genomics in crop plants.
引用
收藏
页码:144 / 151
页数:8
相关论文
共 65 条
[1]   RNA-dependent RNA polymerases, viruses, and RNA silencing [J].
Ahlquist, P .
SCIENCE, 2002, 296 (5571) :1270-1273
[2]   A viral suppressor of gene silencing in plants [J].
Anandalakshmi, R ;
Pruss, GJ ;
Ge, X ;
Marathe, R ;
Mallory, AC ;
Smith, TH ;
Vance, VB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13079-13084
[3]   Transgenic tobacco expressing geminiviral RNAs are resistant to the serious viral pathogen causing cotton leaf curl disease [J].
Asad, S ;
Haris, WAA ;
Bashir, A ;
Zafar, Y ;
Malik, KA ;
Malik, NN ;
Lichtenstein, CP .
ARCHIVES OF VIROLOGY, 2003, 148 (12) :2341-2352
[4]   RNA silencing in plants [J].
Baulcombe, D .
NATURE, 2004, 431 (7006) :356-363
[5]   Role for a bidentate ribonuclease in the initiation step of RNA interference [J].
Bernstein, E ;
Caudy, AA ;
Hammond, SM ;
Hannon, GJ .
NATURE, 2001, 409 (6818) :363-366
[6]   Role of microRNAs in plant and animal development [J].
Carrington, JC ;
Ambros, V .
SCIENCE, 2003, 301 (5631) :336-338
[7]   Broad spectrum resistance to ssDNA viruses associated with transgene-induced gene silencing in cassava [J].
Chellappan, P ;
Masona, MV ;
Vanitharani, R ;
Taylor, NJ ;
Fauquet, CM .
PLANT MOLECULAR BIOLOGY, 2004, 56 (04) :601-611
[8]   Short interfering RNA accumulation correlates with host recovery in DNA virus-infected hosts, and gene silencing targets specific viral sequences [J].
Chellappan, P ;
Vanitharani, R ;
Fauquet, CM .
JOURNAL OF VIROLOGY, 2004, 78 (14) :7465-7477
[9]   Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa [J].
Cogoni, C ;
Macino, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10233-10238
[10]   Plants combat infection by gene silencing [J].
Covey, SN ;
AlKaff, NS ;
Langara, A ;
Turner, DS .
NATURE, 1997, 385 (6619) :781-782