Design and synthesis of conformationally constrained glycosylated amino acids

被引：35

作者：

Koviach, JL ^{[1
]}

Chappell, MD ^{[1
]}

Halcomb, RL ^{[1
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 07期

关键词：

D O I：

10.1021/jo001512z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

To probe the conformational requirements of O-linked glycoproteins for binding to various enzymes and receptors, two conformationally constrained glycosylated amino acids, 2 and 3, were designed. The analogues were found to represent two potential low energy conformations of the parent conjugate, 1, by molecular modeling. A convergent synthesis of both 2 and 3 from D-galactose and L-methionine is presented.

引用

页码：2318 / 2326

页数：9

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