Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?

被引：64

作者：

Tliba, Omar ^{[1
]}

Amrani, Yassine ^{[1
]}

Panettieri, Reynold A. ^{[1
]}

机构：

[1] Univ Penn, Pulm Allergy & Crit Care Div, Sch Med, Philadelphia, PA 19104 USA

来源：

CHEST | 2008年 / 133卷 / 01期

关键词：

airway remodeling; bronchoconstriction; hyperplasia; hypertrophy;

D O I：

10.1378/chest.07-0262

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

Airway smooth muscle (ASM) plays a central role in regulating bronchomotor tone in patients with asthma. New evidence, however, suggests that ASM may also orchestrate and perpetuate airway inflammation by promoting the recruitment, activation, and trafficking of inflammatory cells in the airways. This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma.

引用

页码：236 / 242

页数：7

共 52 条

[1]

Glucocorticoid receptor localization in normal and asthmatic lung [J].

Adcock, IM ;

Gilbey, T ;

Gelder, CM ;

Chung, KF ;

Barnes, PJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (03) :771-782

[2]

Tumor necrosis factor-α-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells -: Modulation by glucocorticoids and β-agonists [J].

Ammit, AJ ;

Lazaar, AL ;

Irani, C ;

O'Neill, GM ;

Gordon, ND ;

Amrani, Y ;

Penn, RB ;

Panettieri, RA .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2002, 26 (04) :465-474

[3]

Amrani Y, 1999, J IMMUNOL, V163, P2128

[4]

Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-κB signaling pathways [J].

Bachar, O ;

Adner, M ;

Uddman, R ;

Cardell, LO .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (04) :1196-1207

[5]

Expression of lung vascular and airway ICAM-1 after exposure to bacterial lipopolysaccharide [J].

BeckSchimmer, B ;

Schimmer, RC ;

Warner, RL ;

Schmal, H ;

Nordblom, G ;

Flory, CM ;

Lesch, ME ;

Friedl, HP ;

Schrier, DJ ;

Ward, PA .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1997, 17 (03) :344-352

[6]

Expression of RANTES mRNA and protein in airways of patients with mild asthma [J].

Berkman, N ;

Krishnan, VL ;

Gilbey, T ;

Newton, R ;

OConnor, B ;

Barnes, PJ ;

Chung, KF .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (06) :1804-1811

[7]

Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling [J].

Bonacci, J. V. ;

Schuliga, M. ;

Harris, T. ;

Stewart, A. G. .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 149 (04) :365-373

[8]

INTERLEUKIN-4, INTERLEUKIN-5, AND INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA IN NORMAL AND ASTHMATIC AIRWAYS - EVIDENCE FOR THE HUMAN MAST-CELL AS A SOURCE OF THESE CYTOKINES [J].

BRADDING, P ;

ROBERTS, JA ;

BRITTEN, KM ;

MONTEFORT, S ;

DJUKANOVIC, R ;

MUELLER, R ;

HEUSSER, CH ;

HOWARTH, PH ;

HOLGATE, ST .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1994, 10 (05) :471-480

[9]

Environmental exposure to endotoxin and its relation to asthma in school-age children [J].

Braun-Fahrländer, C ;

Riedler, J ;

Herz, U ;

Eder, W ;

Waser, M ;

Grize, L ;

Maisch, S ;

Carr, D ;

Gerlach, F ;

Bufe, A ;

Lauener, RP ;

Schierl, R ;

Renz, H ;

Nowak, D ;

von Mutius, E .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :869-877

[10]

The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle [J].

Brightling, CE ;

Ammit, AJ ;

Kaur, D ;

Black, JL ;

Wardlaw, AJ ;

Hughes, JM ;

Bradding, P .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (10) :1103-1108

← 1 2 3 4 5 6 →