Adipokines: Therapeutic targets for metabolic syndrome

被引：60

作者：

Kobayashi, K ^{[1
]}

Inoguchi, T ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Higashi Ku, Fukuoka 8128582, Japan

来源：

CURRENT DRUG TARGETS | 2005年 / 6卷 / 04期

关键词：

D O I：

10.2174/1389450054021972

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

For a long time it has been known that obesity (adiposity) is linked to insulin resistance. Recently, many investigators have reported that adipocytes secrete a variety of bioactive molecules, termed adipokines (adipocytokines), including TNF alpha, IL-6, leptin, adiponectin, resistin and so on. These adipokines play pivotal roles in energy homeostasis by affecting insulin sensitivity, glucose and lipid metabolisms, food intake, the coagulation system and inflammation. This review provides a summary of these adipose tissue-secreting biomolecules and discusses their feasibilities as drug targets for the treatment of metabolic syndrome.

引用

页码：525 / 529

页数：5

共 67 条

[1] Decreased plasma adiponectin concentration in patients with essential hypertension [J].

Adamczak, M ;

Wiecek, A ;

Funahashi, T ;

Chudek, J ;

Kokot, F ;

Matsuzawa, Y .

AMERICAN JOURNAL OF HYPERTENSION, 2003, 16 (01) :72-75

[2] Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Maeda, K ;

Kuriyama, H ;

Okamoto, Y ;

Kumada, M ;

Hotta, K ;

Nishida, M ;

Takahashi, M ;

Nakamura, T ;

Shimomura, I ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

CIRCULATION, 2002, 105 (24) :2893-2898

[3] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Takahashi, M ;

Maeda, K ;

Miyagawa, J ;

Hotta, K ;

Shimomura, I ;

Nakamura, T ;

Miyaoka, K ;

Kuriyama, H ;

Nishida, M ;

Yamashita, S ;

Okubo, K ;

Matsubara, K ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83

[4] Correlation between serum resistin level and adiposity in obese individuals [J].

Azuma, K ;

Katsukawa, F ;

Oguchi, S ;

Murata, M ;

Yamazaki, H ;

Shimada, A ;

Saruta, T .

OBESITY RESEARCH, 2003, 11 (08) :997-1001

[5] Regulation of fasted blood glucose by resistin [J].

Banerjee, RR ;

Rangwala, SM ;

Shapiro, JS ;

Rich, AS ;

Rhoades, B ;

Qi, Y ;

Wang, J ;

Rajala, MW ;

Pocai, A ;

Scherer, PE ;

Steppan, CM ;

Ahima, RS ;

Obici, S ;

Rossetti, L ;

Lazar, MA .

SCIENCE, 2004, 303 (5661) :1195-1198

[6] Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro [J].

Bastard, JP ;

Maachi, M ;

Van Nhieu, JT ;

Jardel, C ;

Bruckert, E ;

Grimaldi, A ;

Robert, JJ ;

Capeau, J ;

Hainque, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (05) :2084-2089

[7] Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss [J].

Bastard, JP ;

Jardel, C ;

Bruckert, E ;

Blondy, P ;

Capeau, J ;

Laville, M ;

Vidal, H ;

Hainque, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (09) :3338-3342

[8] Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat - Evidence of differences between visceral and subcutaneous deposits [J].

Bastelica, D ;

Morange, P ;

Berthet, B ;

Borghi, H ;

Lacroix, O ;

Grino, M ;

Juhan-Vague, I ;

Alessi, MC .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (01) :173-178

[9] The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors [J].

Baumann, H ;

Morella, KK ;

White, DW ;

Dembski, M ;

Bailon, PS ;

Kim, HK ;

Lai, CF ;

Tartaglia, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8374-8378

[10] The adipocyte-secreted protein Acrp30 enhances hepatic insulin action [J].

Berg, AH ;

Combs, TP ;

Du, XL ;

Brownlee, M ;

Scherer, PE .

NATURE MEDICINE, 2001, 7 (08) :947-953

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