Is ACPA positivity the main driver for rheumatoid arthritis treatment? Pros and cons

被引：23

作者：

Alivernini, Stefano ^{[1
]}

Galeazzi, Mauro ^{[2
]}

Peleg, Hagit ^{[3
]}

Tolusso, Barbara ^{[1
]}

Gremese, Elisa ^{[1
]}

Ferraccioli, Gianfranco ^{[1
]}

Naparstek, Yaakov ^{[3
]}

机构：

[1] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Inst Rheumatol, Via Giuseppe Moscati 31, I-00168 Rome, Italy

[2] Univ Siena, Dept Med Sci Surg & Neurosci, Rheumatol Unit, Siena, Italy

[3] Hadassah Hebrew Univ, Dept Med, Med Ctr, POB 12000, Jerusalem, Israel

来源：

AUTOIMMUNITY REVIEWS | 2017年 / 16卷 / 11期

关键词：

Rheumatoid arthritis; Anti-citrullinated peptide antibodies; Biomarker; CYCLIC CITRULLINATED PEPTIDE; ANTICITRULLINATED PROTEIN ANTIBODIES; RADIOGRAPHIC PROGRESSION; AMERICAN-COLLEGE; DISEASE-ACTIVITY; BONE LOSS; B-CELL; AUTOANTIBODIES; DIAGNOSIS; CRITERIA;

D O I：

10.1016/j.autrev.2017.09.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared to seronegative RA. Moreover, ACPA status is associated with favorable response to biologics targeting pathways involving autoantibody producing cells as B lymphocytes. In the current review we have discussed the pros and cons on the available scientific evidences, regarding the diagnostic, prognostic and management implications of ACPAs in RA. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1096 / 1102

页数：7

共 92 条

[1]

Evaluation of the association between anticarbamylated protein antibodies and the longitudinal course of functional ability in rheumatoid arthritis [J].

Ajeganova, S. ;

Svensson, B. ;

Huizinga, T. W. J. ;

van der Helm-van Mil, A. H. M. ;

van Steenbergen, H. W. .

ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (04) :E14-U5

[2]

Rheumatoid factor, not antibodies against citrullinated proteins, is associated with baseline disease activity in rheumatoid arthritis clinical trials [J].

Aletaha, Daniel ;

Alasti, Farideh ;

Smolen, Josef S. .

ARTHRITIS RESEARCH & THERAPY, 2015, 17

[3]

Rheumatoid factor determines structural progression of rheumatoid arthritis dependent and independent of disease activity [J].

Aletaha, Daniel ;

Alasti, Farideh ;

Smolen, Josef S. .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (06) :875-880

[4]

2010 Rheumatoid Arthritis Classification Criteria An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative [J].

Aletaha, Daniel ;

Neogi, Tuhina ;

Silman, Alan J. ;

Funovits, Julia ;

Felson, David T. ;

Bingham, Clifton O., III ;

Birnbaum, Neal S. ;

Burmester, Gerd R. ;

Bykerk, Vivian P. ;

Cohen, Marc D. ;

Combe, Bernard ;

Costenbader, Karen H. ;

Dougados, Maxime ;

Emery, Paul ;

Ferraccioli, Gianfranco ;

Hazes, Johanna M. W. ;

Hobbs, Kathryn ;

Huizinga, Tom W. J. ;

Kavanaugh, Arthur ;

Kay, Jonathan ;

Kvien, Tore K. ;

Laing, Timothy ;

Mease, Philip ;

Menard, Henri A. ;

Moreland, Larry W. ;

Naden, Raymond L. ;

Pincus, Theodore ;

Smolen, Josef S. ;

Stanislawska-Biernat, Ewa ;

Symmons, Deborah ;

Tak, Paul P. ;

Upchurch, Katherine S. ;

Vencovsky, Jiri ;

Wolfe, Frederick ;

Hawker, Gillian .

ARTHRITIS AND RHEUMATISM, 2010, 62 (09) :2569-2581

[5]

Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis [J].

Alivernini, S. ;

Fedele, A. L. ;

Cuoghi, I. ;

Tolusso, B. ;

Ferraccioli, G. .

REUMATISMO, 2008, 60 (02) :85-94

[6]

MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis [J].

Alivernini, Stefano ;

Kurowska-Stolarska, Mariola ;

Tolusso, Barbara ;

Benvenuto, Roberta ;

Elmesmari, Aziza ;

Canestri, Silvia ;

Petricca, Luca ;

Mangoni, Antonella ;

Fedele, Anna Laura ;

Di Mario, Clara ;

Gigante, Maria Rita ;

Gremese, Elisa ;

McInnes, Iain B. ;

Ferraccioli, Gianfranco .

NATURE COMMUNICATIONS, 2016, 7

[7]

Circulating anti-citrullinated peptide antibodies, cytokines and genotype as biomarkers of response to disease-modifying antirheumatic drug therapy in early rheumatoid arthritis [J].

Ally, Mahmood M. T. M. ;

Hodkinson, Bridget ;

Meyer, Pieter W. A. ;

Musenge, Eustasius ;

Tintinger, Gregory R. ;

Tikly, Mohammed ;

Anderson, Ronald .

BMC MUSCULOSKELETAL DISORDERS, 2015, 16

[8]

Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden [J].

Arlestig, Lisbeth ;

Mullazehi, Mohammed ;

Kokkonen, Heidi ;

Rocklov, Joacim ;

Ronnelid, Johan ;

Dahlqvist, Solbritt Rantapaa .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (06) :825-829

[9]

The impact of glycosylation on the biological function and structure of human immunoglobulins [J].

Arnold, James N. ;

Wormald, Mark R. ;

Sim, Robert B. ;

Rudd, Pauline M. ;

Dwek, Raymond A. .

ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :21-50

[10]

Association of rheumatoid factors and anti-filaggrin antibodies with severity of erosions in rheumatoid arthritis [J].

Bas, S ;

Perneger, TV ;

Mikhnevitch, E ;

Seitz, M ;

Tiercy, JM ;

Roux-Lombard, P ;

Guerne, PA .

RHEUMATOLOGY, 2000, 39 (10) :1082-1088

← 1 2 3 4 5 6 7 8 9 10 →