Review of pharmacokinetics and pharmacodynamics of antimicrobial agents

被引：30

作者：

Estes, L ^{[1
]}

机构：

[1] Mayo Clin, Hosp Pharm Serv, Rochester, MN 55905 USA

来源：

MAYO CLINIC PROCEEDINGS | 1998年 / 73卷 / 11期

关键词：

D O I：

10.4065/73.11.1114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pharmacokinetics is a science that has long been used in ascertaining the appropriate antimicrobial dose. It refers to the disposition of drugs in the body and includes absorption, bioavailability, distribution, protein binding, metabolism, and elimination. Pharmacodynamics is a newer science that relates to the interaction between the drug concentration at the site of action over time and the desired antimicrobial effect. This article reviews the principles of pharmacokinetics and pharmacodynamics as well as the clinical application of these two sciences to design antimicrobial dosing regimens for optimal results in individual patients.

引用

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页码：1114 / 1122

页数：9

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