Postnatal expression of VEGF and its receptor flk-1 in peripheral ganglia

The postnatal (P0-P12) and adult expression of vascular endothelial growth factor and its receptor flk-l was investigated in superior cervical (SCG) and dorsal root ganglia (DRG) in mice by immunocytochemistry. At PO all neurons in SCG and DRG contained VEGF. The number of VEGF-immunoreactive neurons in DRG but not in SCG, decreased postnatally and reached adult levels (34%) at P12. At P0 flk-I was found in virtually all neurons in the SCG and in roughly half of the neurons in DRG. The number of flk-l positive neurons then decreased and reached adult levels at P12. The findings demonstrate temporal changes in VEGF and flk-l expression, suggesting developmental regulation of VEGF activity in peripheral ganglia. NeuroReport 12:105-108 (C) 2001 Lippincott Williams & Wilkins.