The Free Radical Fantasy A Panoply of Paradoxes

被引：69

作者：

Howes, Randolph M. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

[2] Univ Santo Tomas, Manila, Philippines

来源：

UNDERSTANDING AND MODULATING AGING | 2006年 / 1067卷

关键词：

oxidants; antioxidants; redox; free radical theory; aging; anti-aging; vitamins;

D O I：

10.1196/annals.1354.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Overly exuberant and exaggerated past expectations and claims of the free radical theory have been quieted by extensive randomized, double-blind, controlled human studies. A half century of data demonstrates its lack of predictability and it has not been validated by the scientific method. Widespread use of antioxidants has failed to quell the current pandemic of cancer, diabetes, and cardiovascular disease or to stop or reverse the aging process. Electronically modified oxygen derivatives contribute to the modulation of cellular redox status, which is of primary importance in disease prevention and homeostasis.

引用

页码：22 / 26

页数：5

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