Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism

被引：372

作者：

Kudo, O

Sabokbar, A

Pocock, A

Itonaga, I

Fujikawa, Y

Athanasou, NA

机构：

[1] Univ Oxford, Nuffield Dept Orthopaed Surg, Dept Pathol, Oxford OX3 7LD, England

[2] Oita Med Univ, Dept Orthopaed Surg, Oita 8795593, Japan

来源：

BONE | 2003年 / 32卷 / 01期

基金：

英国惠康基金;

关键词：

osteoclast; interleukin-6 (IL-6); interleukin-11 (IL-11); glycoprotein 130 (gp-130); bone resorption;

D O I：

10.1016/S8756-3282(02)00915-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-6 (IL-6) and interleukin-11 (IL-11) are known to influence osteoclast formation and bone resorption. In order to determine whether IL-6 and IL-11 could independently support human osteoclast formation, these factors were added to cultures of human peripheral blood mononuclear cells of the monocyte (CD14(+)) fraction in the presence of macrophage colony-stimulating factor (M-CSF). Under these conditions, IL-6 and IL-11 induced the formation of multinucleated cells which were positive for TRAP, VNR, and calcitonin receptor and capable of lacunar resorption. Osteoclastogenesis induced by IL-6 and IL-11 was inhibited by the addition of an anti-gp130 antibody but not by osteoprotegerin. These results indicate that IL-6 and IL-11, which are thought to play a role in several osteolytic bone disorders, are directly capable of inducing osteoclast formation by a RANKL-independent mechanism. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：1 / 7

页数：7

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