Mitochondrial energy metabolism in heart failure: a question of balance

被引：422

作者：

Huss, JM

Kelly, DP ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Cardiovasc Res Ctr, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 03期

关键词：

D O I：

10.1172/JCI200524405

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.

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页码：547 / 555

页数：9

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