Substrate-Controlled Regioselective Cobalt(I)-Catalysed 1,4-Hydrovinylation Reactions

被引：27

作者：

Hilt, Gerhard ^{[1
]}

Roesner, Stefan ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany

来源：

SYNTHESIS-STUTTGART | 2011年 / 04期

关键词：

alkene; catalysis; cobalt; diene; regioselectivity; COBALT-CATALYZED 1,4-HYDROVINYLATION; ASYMMETRIC HYDROVINYLATION; ORGANIC-SYNTHESIS; ENYNE METATHESIS; ALDER REACTION; 1,3-DIENES; ALKYNES; DERIVATIVES; STYRENES; LIGANDS;

D O I：

10.1055/s-0030-1258408

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The substrate-directed regiochemistry of the cobalt-catalysed 1,4-hydrovinylation reaction is described. A variety of symmetrical and unsymmetrical 2,3-disubstituted 1,3-dienes are synthesised by ruthenium-catalysed enyne metathesis, and then reacted with a terminal alkene catalysed by cobalt(II) bromide-[1,2-bis(diphenylphosphino)ethane] [CoBr2(dppe)] under reductive conditions. The regiochemistry of the branched 1,4-diene products is influenced by the nature of the substituents on the unsymmetrical 2,3-disubstituted 1,3-dienes. The influence of steric and electronic effects is also discussed.

引用

页码：662 / 668

页数：7

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