Heparan sulfate proteoglycans in the nervous system: their diverse roles in neurogenesis, axon guidance, and synaptogenesis

被引:118
作者
Yamaguchi, Y [1 ]
机构
[1] Burnham Inst, Neurobiol Program, La Jolla, CA 92037 USA
关键词
axon guidance; dendritic spine; heparan sulfate proteoglycan; neurogenesis; synapse;
D O I
10.1006/scdb.2000.0238
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Development of the mammalian nervous system involves generation of neurons from neural stem cells, migration of generated neurons toward genetically determined locations, extension of axons and dendrites, and establishment of neuronal connectivity. Recent progresses revealed diverse role Of heparan sulfate proteoglycans in these processes. This article reviews our current knowledge about the functional roles of heparan sulfate proteoglycans in three critical events in mammalian neural development, namely neurogenesis, axon guidance, and synapse development.
引用
收藏
页码:99 / 106
页数:8
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