Combination effect of vancomycin and β-lactams against a Staphylococcus aureus strain, Mu3, with heterogeneous resistance to vancomycin

被引：27

作者：

Aritaka, N ^{[1
]}

Hanaki, H ^{[1
]}

Cui, LZ ^{[1
]}

Hiramatsu, K ^{[1
]}

机构：

[1] Juntendo Univ, Dept Bacteriol, Bunkyo Ku, Tokyo 1138421, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 04期

关键词：

D O I：

10.1128/AAC.45.4.1292-1294.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We tested the combined activity of vancomycin and seven beta -lactam antibiotics against Staphylococcus aureus clinical strain Mu3, which displays heterogeneous resistance to vancomycin, When combined with vancomycin, four of the seven tested beta -Lactams exhibited an additive effect at or near their MICs, while all showed an antagonistic effect at lower, sub-MIC levels. This study implicated the unpredictable nature of combination therapy of beta -lactams and vancomycin against S. aureus with reduced susceptibility to vancomycin.

引用

页码：1292 / 1294

页数：3

共 24 条

[1]

Asada K, 1995, ACTA BIOCHIM POL, V42, P517

[2] INVITRO ANTIMICROBIAL ACTIVITY OF IMIPENEM IN COMBINATION WITH VANCOMYCIN OR TEICOPLANIN AGAINST STAPHYLOCOCCUS-AUREUS AND STAPHYLOCOCCUS-EPIDERMIDIS [J].

BARR, JG ;

SMYTH, ETM ;

HOGG, GM .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1990, 9 (11) :804-809

[3] BINDING OF BETA-LACTAM ANTIBIOTICS TO PENICILLIN-BINDING PROTEINS IN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS [J].

CHAMBERS, HF ;

SACHDEVA, M .

JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (06) :1170-1176

[4] Combinations of vancomycin and β-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin [J].

Climo, MW ;

Patron, RL ;

Archer, GL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (07) :1747-1753

[5] PENICILLIN-BINDING PROTEINS IN BACTERIA [J].

GEORGOPAPADAKOU, NH ;

LIU, FY .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (01) :148-157

[6] Outbreak of methicillin-resistant Staphylococcus aureus with reduced susceptibility to glycopeptides in a Parisian hospital [J].

Guerin, F ;

Buu-Hoï, A ;

Mainardi, JL ;

Kac, G ;

Colardelle, N ;

Vaupré, S ;

Gutmann, L ;

Podglajen, I .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (08) :2985-2988

[7] Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50 [J].

Hanaki, H ;

Kuwahara-Arai, K ;

Boyle-Vavra, S ;

Daum, RS ;

Labischinski, H ;

Hiramatsu, K .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (02) :199-209

[8]

Hanaki Hideaki, 1998, Japanese Journal of Antibiotics, V51, P521

[9] The effects of vancomycin and (beta)-lactam antibiotics on vancomycin-resistant Staphylococcus aureus. [J].

Haraga, I ;

Nomura, S ;

Nagayama, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (21) :1624-1624

[10] LOW-AFFINITY PENICILLIN-BINDING PROTEIN ASSOCIATED WITH BETA-LACTAM RESISTANCE IN STAPHYLOCOCCUS-AUREUS [J].

HARTMAN, BJ ;

TOMASZ, A .

JOURNAL OF BACTERIOLOGY, 1984, 158 (02) :513-516

← 1 2 3 →