Nonconvulsive status epilepticus on treatment with levetiracetam

被引:22
作者
Atefy, R [1 ]
Tettenborn, B [1 ]
机构
[1] Kantonsspital St Gallen, Dept Neurol, CH-9007 St Gallen, Switzerland
关键词
levetiracetam; nonconvulsive status epilepticus; epilepsy; anticonvulsive treatment;
D O I
10.1016/j.yebeh.2005.03.015
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In several Studies the efficacy and tolerability of levetiracetam (LEV) have been demonstrated. We report two patients who developed nonconvulsive status epilepticus on treatment with LEV. Both patients never experienced status epilepticus before. One patient had a symptomatic epilepsy with complex partial seizures following radiotherapy of astrocytoma in 1985; the second patient had complex partial seizures due to mesial temporal sclerosis. Both patients received LEV 2000 mg/day. We postulate a correlation between occurrence of nonconvulsive status and treatment with LEV. This has not been described before apart from a single report of mentally retarded patients with status epilepticus on high dosages of LEV. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:613 / 616
页数:4
相关论文
共 12 条
[1]   Seizure-inducing effects of antiepileptic drugs: A review [J].
Bauer, J .
ACTA NEUROLOGICA SCANDINAVICA, 1996, 94 (06) :367-377
[2]   Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: A multicenter, double-blind, responder-selected study evaluating monotherapy [J].
Ben-Menachem, E ;
Falter, T .
EPILEPSIA, 2000, 41 (10) :1276-1283
[3]   Efficacy and tolerability of levetiracetam during 1-year follow-up in patients with refractory epilepsy [J].
Ben-Menachem, E ;
Gilland, E .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2003, 12 (03) :131-135
[4]   A multicentre, double-blind, randomized, parallel group study to evaluate the tolerability and efficacy of two oral doses of levetiracetam, 2000 mg daily and 4000 mg daily, without titration in patients with refractory epilepsy [J].
Betts, T ;
Waegemans, T ;
Crawford, P .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2000, 9 (02) :80-87
[5]   Dose-response effect of levetiracetam 1000 and 2000 mg/day in partial epilepsy [J].
Boon, P ;
Chauvel, P ;
Pohlmann-Eden, B ;
Otoul, C ;
Wroe, S .
EPILEPSY RESEARCH, 2002, 48 (1-2) :77-89
[6]   Levetiracetam for partial seizures - Results of a double-blind, randomized clinical trial [J].
Cereghino, JJ ;
Biton, V ;
Abou-Khalil, B ;
Dreifuss, F ;
Gauer, LJ ;
Leppik, I .
NEUROLOGY, 2000, 55 (02) :236-242
[7]   Nonconvulsive status epilepticus in two patients receiving tiagabine treatment [J].
Eckardt, KM ;
Steinhoff, BJ .
EPILEPSIA, 1998, 39 (06) :671-674
[8]   A paradoxical effect of levetiracetam may be seen in both children and adults with refractory epilepsy [J].
Nakken, KO ;
Eriksson, AS ;
Lossius, R ;
Johannessen, SI .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2003, 12 (01) :42-46
[9]  
NEUFELD MY, 2002, BRAIN DIS THERAPEUTI, P251
[10]   Antiepileptic drugs as a cause of worsening seizures [J].
Perucca, E ;
Gram, L ;
Avanzini, G ;
Dulac, O .
EPILEPSIA, 1998, 39 (01) :5-17